tert-butyl 3-(1-hydroxyethyl)azetidine-1-carboxylate

tert-butyl 3-(1-hydroxyethyl)azetidine-1-carboxylate - Names and Identifiers

Name	1-Boc-3-(1-hydroxyethyl)-azetidine
Synonyms	1-Boc-3-(1-hydroxyethyl)-azetidine tert-butyl 3-(1-hydroxyethyl)azetidine-1-carboxylate 1-Azetidinecarboxylic acid, 3-(1-hydroxyethyl)-, 1,1-dimethylethyl ester
CAS	1138331-90-4

tert-butyl 3-(1-hydroxyethyl)azetidine-1-carboxylate - Physico-chemical Properties

Molecular Formula	C10H19NO3
Molar Mass	201.26
Storage Condition	2-8℃

tert-butyl 3-(1-hydroxyethyl)azetidine-1-carboxylate - Introduction

1-Boc-3-(1-hydroxyethyl) azetidine is an organic compound with the following properties:
-Chemical formula: C15H25NO4
-Molecular weight: 279.36g/mol
-Appearance: White crystalline solid
-melting point: 58-61 ℃

Some of the main uses of this compound include:
-Organic synthesis: As a protecting group, it can be selectively protected by the substrate to prevent other reactions from occurring. Once the synthesis of the substrate is complete, this group can be removed by an appropriate deprotection reaction.
-Drug synthesis: as an intermediate to expand the chemical synthesis of peptides and drugs.
-Chemical biology research: used for drug design and biological activity research.

The preparation method of 1-Boc-3-(1-hydroxyethyl) azetidine usually includes the following steps:
1. azetidine and tert-butyl carbonate react under alkaline conditions to produce 1-Boc-3-azetidine.
2.1-Boc-3-azetidine is subjected to a reduction reaction with an aldehyde compound in the presence of hydrogen and a catalyst to obtain 1-Boc-3-(1-hydroxyethyl) azetidine.

Safety information about the compound:
1-Boc-3-(1-hydroxyethyl) azetidine generally has low toxicity under normal operating conditions. However, as an organic compound, it is still necessary to take appropriate laboratory safety measures, such as wearing personal protective equipment and avoiding direct contact with skin and eyes. At the same time, avoid inhaling gas and dust and ensure that the operation is carried out in a well-ventilated laboratory environment. If exposed or inhaled, seek medical help immediately.

Last Update：2024-04-09 21:54:55